By law, major defense acquisition programs are now required to prepare cost estimates earlier in the acquisition lifecycle, including pre-Milestone A, well before concrete technical information is available on the program being developed. Estimates are therefore often based on a desired capability—or even on an abstract concept—rather than a concrete technical solution plan to achieve the desired capability. Hence the role and modeling of assumptions becomes more challenging. This blog posting outlines a multi-year project on Quantifying Uncertainty in Early Lifecycle Cost Estimation (QUELCE) conducted by the SEI Software Engineering Measurement and Analysis (SEMA) team. QUELCE is a method for improving pre-Milestone A software cost estimates through research designed to improve judgment regarding uncertainty in key assumptions (which we term program change drivers), the relationships among the program change drivers, and their impact on cost.